Polyclonal Antibody against Human RBP4
Size: 0.1 mg
Introduction
Retinol binding protein 4 (RBP4), originally known as a specific transport of retinol in blood, is also a novel inflammatory and insulin
resistance marker. Serum RBP4 levels are elevated in insulin resistant mice and humans with obesity and type 2 diabetes. Animal
experiments found that increased secretion of RBP4 might reduce insulin-dependent glucose uptake by muscle tissue by reducing
the activity of phosphoinositide 3-kinase (PI(3)K), and increased hepatic glucose output by increasing the expression of the enzyme PEPCK2. Studies suggested that elevated serum RBP4 was associated with components of the metabolic syndrome, including
increased body-mass index, waist-to-hip ratio, serum triglyceride levels and systolic blood pressure, and decreased high-density
lipoprotein cholesterol levels. Furthermore, circulating RBP4 concentrations were associated with subclinical cardiovascular disease, which imply that RBP4 could be involved in the development of atherosclerosis.
Purification
Antigen affinity-purified
Immunogen
Recombinant full-length human RBP4 expressed in E.coli.
Specificity
The antibody can detect human RBP4 in western blot and ELISA.
Formulation
Liquid in phosphate-buffered saline (PBS).
Storage
Store at –20°C for less than one week. For long-term storage, aliquot and freeze at -70°C. Avoid repeated freeze/defrost cycles.
Application/Usage
Western blot - This antibody can be used as primary antibody in western blot assay to detect human RBP4.
ELISA - This antibody can be used in ELISA with the appropriate secondary reagents to detect human RBP4.
