C-reactive protein (CRP) is a circulating protein mainly secreted from the liver. This acute phase protein consists of five identical non-glycosylated subunits of 23 kDa, that give rise to a symmetrically arranged globular protein with molecular weight of approximately 120 kDa. It has long been recognized that CRP is closely related to immunology, inflammation and host defence, as a result it has been used as an inflammatory marker. There is accumulating evidence suggesting the important role that CRP plays in mediating cardiovascular diseases (CVD) and type 2 diabetes. Normally CRP is presenting only in a trace amount in circulation (<1 µg/ml) but can increase over 1,000-fold under acute inflammatory state. Individual with blood CRP levels <1 µg/ml, 1-3 µg/ml and >3 µg/ml is considered to have low, moderate and high risk, respectively, of CVD and myocardial infraction. Therefore, blood CRP level has become a promising measure of CVD risk.
Rabbit IgG was purified by protein-G column. Immunogen: Recombinant Human C- reactive Protein (CRP) expressed in E.coli.
The antibody detects human CRP. Formulation: Solution in PBS.
Store at –20°C. For long-term storage, aliquot and freeze at -70°C. Avoid repeated freeze/defrost cycles.
ELISA - This antibody can be used at 0.1 – 0.2 µg/ml with the appropriate secondary reagents to detect human CRP.
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