FGF21, a polypeptide with 210 amino acid residues produced mostly from the liver tissue. Mouse FGF21 shares 75% identity as human FGF21. Recent animal studies indicate it possesses potent beneﬁcial effects on glucose and lipid metabolism and insulin sensitivity. Increasing data shows FGF21 can significantly stimulate glucose uptake in mature adipocytes. And The lowered LDL-cholesterol and increased HDL-cholesterol can also be observed. FGF21 exerts its bioactivity through interaction with membrane-bound FGF receptors (FGFRs) which requires β-Klotho as a co-factor to bind and activate FGFR signaling. The activation of FGF21 can induce the stimulation of diverse downstream pathways mediated by MAPK,FRS-2, SHP-2, PI3K, raf, stat and other signaling molecules. In sum, FGF21 induces a variety of significant beneficial metabolic changes without apparent adverse effects which makes this factor a hot candidate to treat some metabolic diseases.
Total 206AA Mw: 22.5kDa (calculated). N-terminal His-tag and TEV cleavage site, 25extra AA (highlighted).